There are
1,642 mi
from Cheyenne, WY to Lexington, SC
That's the driving distance. It would take 1 day 5 hours to go from Cheyenne, Wyoming to Lexington, South Carolina.
The flight distance (direct flight from Cheyenne, WY to Lexington, SC) is 1,377.78 mi.
1,642 mi = 2,642.86 kms