There are
1,728 mi
from Cheyenne, WY to Lake City, FL
That's the driving distance. It would take 1 day 7 hours to go from Cheyenne, Wyoming to Lake City, Florida.
The flight distance (direct flight from Cheyenne, WY to Lake City, FL) is 1,450.52 mi.
1,728 mi = 2,781.18 kms