There are
1,787 mi
from Cheyenne, WY to Jacksonville, FL
That's the driving distance. It would take 1 day 8 hours to go from Cheyenne, Wyoming to Jacksonville, Florida.
The flight distance (direct flight from Cheyenne, WY to Jacksonville, FL) is 1,491.54 mi.
1,787 mi = 2,875.09 kms