There are
1,806 mi
from Cheyenne, WY to Jacksonville Beach, FL
That's the driving distance. It would take 1 day 8 hours to go from Cheyenne, Wyoming to Jacksonville Beach, Florida.
The flight distance (direct flight from Cheyenne, WY to Jacksonville Beach, FL) is 1,505.98 mi.
1,806 mi = 2,907.24 kms