There are
1,844 mi
from Cheyenne, WY to Holyoke, MA
That's the driving distance. It would take 1 day 9 hours to go from Cheyenne, Wyoming to Holyoke, Massachusetts.
The flight distance (direct flight from Cheyenne, WY to Holyoke, MA) is 1,653.77 mi.
1,844 mi = 2,967.80 kms