There are
491 mi
from Cheyenne, WY to Great Bend, KS
That's the driving distance. It would take 8 hours 28 mins to go from Cheyenne, Wyoming to Great Bend, Kansas.
The flight distance (direct flight from Cheyenne, WY to Great Bend, KS) is 374.34 mi.
491 mi = 789.85 kms