There are
1,197 mi
from Cheyenne, WY to Clarksdale, MS
That's the driving distance. It would take 20 hours 48 mins to go from Cheyenne, Wyoming to Clarksdale, Mississippi.
The flight distance (direct flight from Cheyenne, WY to Clarksdale, MS) is 913.22 mi.
1,197 mi = 1,925.75 kms