There are
1,269 mi
from Cheyenne, WY to Chillicothe, OH
That's the driving distance. It would take 23 hours 7 mins to go from Cheyenne, Wyoming to Chillicothe, Ohio.
The flight distance (direct flight from Cheyenne, WY to Chillicothe, OH) is 1,155.50 mi.
1,269 mi = 2,041.79 kms