There are
1,601 mi
from Cheyenne, WY to Charlotte, NC
That's the driving distance. It would take 1 day 5 hours to go from Cheyenne, Wyoming to Charlotte, North Carolina.
The flight distance (direct flight from Cheyenne, WY to Charlotte, NC) is 1,359.68 mi.
1,601 mi = 2,576.52 kms