There are
1,018 mi
from Cheyenne, WY to Appleton, WI
That's the driving distance. It would take 18 hours 33 mins to go from Cheyenne, Wyoming to Appleton, Wisconsin.
The flight distance (direct flight from Cheyenne, WY to Appleton, WI) is 858.82 mi.
1,018 mi = 1,638.63 kms