There are
919 mi
from Chesapeake, VA to Cape Girardeau, MO
That's the driving distance. It would take 17 hours 13 mins to go from Chesapeake, Virginia to Cape Girardeau, Missouri.
The flight distance (direct flight from Chesapeake, VA to Cape Girardeau, MO) is 730.07 mi.
919 mi = 1,478.73 kms