There are
332 mi
from Chattanooga, TN to Sikeston, MO
That's the driving distance. It would take 6 hours 16 mins to go from Chattanooga, Tennessee to Sikeston, Missouri.
The flight distance (direct flight from Chattanooga, TN to Sikeston, MO) is 270.61 mi.
332 mi = 534.40 kms