There are
603 mi
from Chattanooga, TN to Opelousas, LA
That's the driving distance. It would take 11 hours 8 mins to go from Chattanooga, Tennessee to Opelousas, Louisiana.
The flight distance (direct flight from Chattanooga, TN to Opelousas, LA) is 501.67 mi.
603 mi = 971.22 kms