There are
338 mi
from Chattanooga, TN to Cape Girardeau, MO
That's the driving distance. It would take 6 hours 36 mins to go from Chattanooga, Tennessee to Cape Girardeau, Missouri.
The flight distance (direct flight from Chattanooga, TN to Cape Girardeau, MO) is 281.88 mi.
338 mi = 543.75 kms