There are
2,482 mi
from Charleston, SC to Rancho Santa Margarita, CA
That's the driving distance. It would take 1 day 20 hours to go from Charleston, South Carolina to Rancho Santa Margarita, California.
The flight distance (direct flight from Charleston, SC to Rancho Santa Margarita, CA) is 2,166.45 mi.
2,482 mi = 3.22 kms