Miles between Charleston, SC and Port St Lucie, FL

There are
474 mi
from Charleston, SC to Port St Lucie, FL

That's the driving distance. It would take 8 hours 58 mins to go from Charleston, South Carolina to Port St Lucie, Florida.

The flight distance (direct flight from Charleston, SC to Port St Lucie, FL) is 380.91 mi.

474 mi = 762.57 kms