There are
2,254 mi
from Charleston, SC to Mesquite, NV
That's the driving distance. It would take 1 day 17 hours to go from Charleston, South Carolina to Mesquite, Nevada.
The flight distance (direct flight from Charleston, SC to Mesquite, NV) is 1,946.44 mi.
2,254 mi = 3,627.32 kms