Miles between Charleston, SC and Greeneville, TN

There are
321 mi
from Charleston, SC to Greeneville, TN

That's the driving distance. It would take 6 hours 27 mins to go from Charleston, South Carolina to Greeneville, Tennessee.

The flight distance (direct flight from Charleston, SC to Greeneville, TN) is 286.39 mi.

321 mi = 516.71 kms