Miles between Charleston, SC and Cape Girardeau, MO

There are
755 mi
from Charleston, SC to Cape Girardeau, MO

That's the driving distance. It would take 14 hours 26 mins to go from Charleston, South Carolina to Cape Girardeau, Missouri.

The flight distance (direct flight from Charleston, SC to Cape Girardeau, MO) is 625.68 mi.

755 mi = 1,214.78 kms