There are
387 mi
from Champaign, IL to La Crosse, WI
That's the driving distance. It would take 7 hours 12 mins to go from Champaign, Illinois to La Crosse, Wisconsin.
The flight distance (direct flight from Champaign, IL to La Crosse, WI) is 297.48 mi.
387 mi = 622.32 kms