Miles between Champaign, IL and Kirksville, MO

There are
280 mi
from Champaign, IL to Kirksville, MO

That's the driving distance. It would take 5 hours 16 mins to go from Champaign, Illinois to Kirksville, Missouri.

The flight distance (direct flight from Champaign, IL to Kirksville, MO) is 229.22 mi.

280 mi = 451.24 kms