There are
241 mi
from Champaign, IL to Cape Girardeau, MO
That's the driving distance. It would take 4 hours 32 mins to go from Champaign, Illinois to Cape Girardeau, Missouri.
The flight distance (direct flight from Champaign, IL to Cape Girardeau, MO) is 205.98 mi.
241 mi = 387.64 kms