There are
2,841 mi
from Cary, NC to South San Francisco, CA
That's the driving distance. It would take 2 days 2 hours to go from Cary, North Carolina to South San Francisco, California.
The flight distance (direct flight from Cary, NC to South San Francisco, CA) is 2,397.65 mi.
2,841 mi = 3.22 kms