There are
521 mi
from Carmel, IN to North Tonawanda, NY
That's the driving distance. It would take 9 hours 58 mins to go from Carmel, Indiana to North Tonawanda, New York.
The flight distance (direct flight from Carmel, IN to North Tonawanda, NY) is 430.56 mi.
521 mi = 837.85 kms