There are
324 mi
from Carmel, IN to Cape Girardeau, MO
That's the driving distance. It would take 6 hours 7 mins to go from Carmel, Indiana to Cape Girardeau, Missouri.
The flight distance (direct flight from Carmel, IN to Cape Girardeau, MO) is 260.28 mi.
324 mi = 520.99 kms