Miles between Cape Coral, FL and Florence, SC

There are
624 mi
from Cape Coral, FL to Florence, SC

That's the driving distance. It would take 11 hours 53 mins to go from Cape Coral, Florida to Florence, South Carolina.

The flight distance (direct flight from Cape Coral, FL to Florence, SC) is 543.18 mi.

624 mi = 1,004.65 kms