There are
260 mi
from Bloomington, IN to Cape Girardeau, MO
That's the driving distance. It would take 5 hours 5 mins to go from Bloomington, Indiana to Cape Girardeau, Missouri.
The flight distance (direct flight from Bloomington, IN to Cape Girardeau, MO) is 207.03 mi.
260 mi = 418.44 kms