There are
798 mi
from Asheville, NC to Manitowoc, WI
That's the driving distance. It would take 15 hours 33 mins to go from Asheville, North Carolina to Manitowoc, Wisconsin.
The flight distance (direct flight from Asheville, NC to Manitowoc, WI) is 645.59 mi.
798 mi = 1,284.56 kms