There are
441 mi
from Appleton, WI to Ypsilanti, MI
That's the driving distance. It would take 8 hours 21 mins to go from Appleton, Wisconsin to Ypsilanti, Michigan.
The flight distance (direct flight from Appleton, WI to Ypsilanti, MI) is 279.04 mi.
441 mi = 709.51 kms