There are
1,578 mi
from Appleton, WI to Weslaco, TX
That's the driving distance. It would take 1 day 5 hours to go from Appleton, Wisconsin to Weslaco, Texas.
The flight distance (direct flight from Appleton, WI to Weslaco, TX) is 1,360.24 mi.
1,578 mi = 1.61 kms