There are
905 mi
from Appleton, WI to Tuscaloosa, AL
That's the driving distance. It would take 16 hours 57 mins to go from Appleton, Wisconsin to Tuscaloosa, Alabama.
The flight distance (direct flight from Appleton, WI to Tuscaloosa, AL) is 764.97 mi.
905 mi = 1,456.90 kms