There are
504 mi
from Appleton, WI to South Sioux City, NE
That's the driving distance. It would take 9 hours 57 mins to go from Appleton, Wisconsin to South Sioux City, Nebraska.
The flight distance (direct flight from Appleton, WI to South Sioux City, NE) is 420.21 mi.
504 mi = 811.90 kms