There are
501 mi
from Appleton, WI to Sioux City, IA
That's the driving distance. It would take 9 hours 50 mins to go from Appleton, Wisconsin to Sioux City, Iowa.
The flight distance (direct flight from Appleton, WI to Sioux City, IA) is 418.85 mi.
501 mi = 806.02 kms