There are
2,134 mi
from Appleton, WI to Santee, CA
That's the driving distance. It would take 1 day 14 hours to go from Appleton, Wisconsin to Santee, California.
The flight distance (direct flight from Appleton, WI to Santee, CA) is 1,721.04 mi.
2,134 mi = 3.22 kms