There are
1,317 mi
from Appleton, WI to Sanford, FL
That's the driving distance. It would take 1 day 1 hour to go from Appleton, Wisconsin to Sanford, Florida.
The flight distance (direct flight from Appleton, WI to Sanford, FL) is 1,140.69 mi.
1,317 mi = 1.61 kms