There are
2,205 mi
from Appleton, WI to San Mateo, CA
That's the driving distance. It would take 1 day 14 hours to go from Appleton, Wisconsin to San Mateo, California.
The flight distance (direct flight from Appleton, WI to San Mateo, CA) is 1,816.01 mi.
2,205 mi = 3.22 kms