There are
1,004 mi
from Appleton, WI to Poughkeepsie, NY
That's the driving distance. It would take 18 hours 52 mins to go from Appleton, Wisconsin to Poughkeepsie, New York.
The flight distance (direct flight from Appleton, WI to Poughkeepsie, NY) is 752.62 mi.
1,004 mi = 1,615.78 kms