There are
212 mi
from Appleton, WI to Midlothian, IL
That's the driving distance. It would take 4 hours 8 mins to go from Appleton, Wisconsin to Midlothian, Illinois.
The flight distance (direct flight from Appleton, WI to Midlothian, IL) is 185.56 mi.
212 mi = 341.05 kms