There are
942 mi
from Appleton, WI to Middletown, DE
That's the driving distance. It would take 18 hours 4 mins to go from Appleton, Wisconsin to Middletown, Delaware.
The flight distance (direct flight from Appleton, WI to Middletown, DE) is 732.13 mi.
942 mi = 1,515.45 kms