There are
1,724 mi
from Appleton, WI to Mesquite, NV
That's the driving distance. It would take 1 day 6 hours to go from Appleton, Wisconsin to Mesquite, Nevada.
The flight distance (direct flight from Appleton, WI to Mesquite, NV) is 1,434.86 mi.
1,724 mi = 1.61 kms