There are
280 mi
from Appleton, WI to Mendota Heights, MN
That's the driving distance. It would take 5 hours 24 mins to go from Appleton, Wisconsin to Mendota Heights, Minnesota.
The flight distance (direct flight from Appleton, WI to Mendota Heights, MN) is 236.36 mi.
280 mi = 451.40 kms