There are
2,272 mi
from Appleton, WI to Medford, OR
That's the driving distance. It would take 1 day 16 hours to go from Appleton, Wisconsin to Medford, Oregon.
The flight distance (direct flight from Appleton, WI to Medford, OR) is 1,725.38 mi.
2,272 mi = 3.22 kms