There are
526 mi
from Appleton, WI to Madisonville, KY
That's the driving distance. It would take 10 hours 57 mins to go from Appleton, Wisconsin to Madisonville, Kentucky.
The flight distance (direct flight from Appleton, WI to Madisonville, KY) is 481.46 mi.
526 mi = 846.59 kms