There are
2,134 mi
from Appleton, WI to La Mesa, CA
That's the driving distance. It would take 1 day 14 hours to go from Appleton, Wisconsin to La Mesa, California.
The flight distance (direct flight from Appleton, WI to La Mesa, CA) is 1,726.20 mi.
2,134 mi = 3,434.51 kms