There are
174 mi
from Appleton, WI to La Crosse, WI
That's the driving distance. It would take 3 hours 52 mins to go from Appleton, Wisconsin to La Crosse, Wisconsin.
The flight distance (direct flight from Appleton, WI to La Crosse, WI) is 143.85 mi.
174 mi = 280.59 kms