There are
275 mi
from Appleton, WI to Kewanee, IL
That's the driving distance. It would take 5 hours 28 mins to go from Appleton, Wisconsin to Kewanee, Illinois.
The flight distance (direct flight from Appleton, WI to Kewanee, IL) is 222.02 mi.
275 mi = 442.10 kms