There are
337 mi
from Appleton, WI to Kalamazoo, MI
That's the driving distance. It would take 6 hours 31 mins to go from Appleton, Wisconsin to Kalamazoo, Michigan.
The flight distance (direct flight from Appleton, WI to Kalamazoo, MI) is 196.88 mi.
337 mi = 542.09 kms