There are
497 mi
from Appleton, WI to Jeffersontown, KY
That's the driving distance. It would take 9 hours 37 mins to go from Appleton, Wisconsin to Jeffersontown, Kentucky.
The flight distance (direct flight from Appleton, WI to Jeffersontown, KY) is 444.57 mi.
497 mi = 800.28 kms