There are
888 mi
from Appleton, WI to Hyattsville, MD
That's the driving distance. It would take 16 hours 48 mins to go from Appleton, Wisconsin to Hyattsville, Maryland.
The flight distance (direct flight from Appleton, WI to Hyattsville, MD) is 695.81 mi.
888 mi = 1,428.64 kms