There are
445 mi
from Appleton, WI to Hannibal, MO
That's the driving distance. It would take 8 hours 31 mins to go from Appleton, Wisconsin to Hannibal, Missouri.
The flight distance (direct flight from Appleton, WI to Hannibal, MO) is 348.98 mi.
445 mi = 716.03 kms